America is the world’s richest large economy, with the world’s leading technologies and institutions of higher learning. Yet, the U.S. is falling behind other countries on a range of indicators relating to quality-of-life, economic opportunity, and environmental management. Nowhere is this problem more apparent than in American cities, which are home to 62.7 percent of the domestic population. The SDGs are an opportunity to address many of America’s challenges while building on America’s great reservoirs of dynamism and talent.