The tissue culture and cryopreservation program at The Huntington demonstrates the potential for in vitro collections at botanic gardens and highlights what can be accomplished with a small focused program by using existing capital resources and investing in key qualified staff. This short talk will present an overview of the garden's experience in implementing such a program and discusses current projects, through the dual lens of both costs and conservation utility. The goal of this session is to highlight that even a small program can have a large international impact and botanic gardens have a role to play in cryopreservation research, particularly those gardens that have existing in vitro programs.